Melrose's churches have watched over and provided support to the community since its founding. The earliest churches of Melrose are Eliam Baptist, the Melrose United Methodist Church and Trinity Episcopal Church. The Methodist and Episcopal churches are in their original buildings.
Melrose United Methodist Church has the distinction of having the oldest church building in Melrose. The land was deeded to the church trustees in June, 1879 and the church built shortly afterwards.
Trinity Episcopal Church
Trinity was organized by Bishop John Freeman Young and the building completed in 1886 by a local builder in the "Carpenter Gothic" style developed by the architect, Richard Upjohn. Architect Upjohn and Bishop Young became acquainted when Bishop Young had served as Assistant Rector of Trinity Church, New York City. Numerous churches have been built from the Upjohn plans.
Today, we have many denominations within 15 miles.
The Churches of Melrose
| Church | Phone Number | |
| Believers Worship Center Church | 352.475.1415 | |
| Eliam Baptist Church | 352.475.2820 | |
| Faith Presbyterian Church | 352.475.1721 | |
| Melrose Church of Christ | 352.475.2129 | |
| Melrose Church of God Mountain Assembly | 352.475.2888 | |
| Melrose United Methodist Church | 352.475.2456 | |
| St. Johns Baptist Church | 352.475.1868 | |
| St. William Catholic Church | 352.473.4136 | |
| Trinity Episcopal Church | 352.475.2177 |